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- Title
Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum.
- Authors
Gil-Lamaignere, Cristina; Roilides, Emmanuel; Maloukou, Avgi; Georgopoulou, Irene; Petrikkos, George; Walsh, Thomas J.
- Abstract
Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes (PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2002, Vol 50, Issue 6, p1027
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkf198