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- Title
Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women.
- Authors
Cornette, J.; Duvekot, J. J.; Roos-Hesselink, J. W.; Hop, W. C. J.; Steegers, E. A. P.
- Abstract
Please cite this paper as: Cornette J, Duvekot J, Roos-Hesselink J, Hop W, Steegers E. Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women. BJOG 2011;118:510-515. While nifedipine is commonly used for tocolysis, the controversy on its safety remains. So far, the haemodynamic effects on maternal and fetal circulations have not been well documented. Fifteen normotensive women who received 20 mg nifedipine were included in this prospective observational study. The maternal and fetal haemodynamic effects were analysed using maternal echocardiography and fetal Doppler ultrasonography. Nifedipine induced a significant afterload reduction in all women. It triggered a compensatory increase in cardiac output, which maintained blood pressure. These maternal changes had no influence on the uteroplacental and fetal circulations.
- Subjects
NIFEDIPINE; PREGNANT women; HEMODYNAMICS; CARDIAC output; VASCULAR resistance; ECHOCARDIOGRAPHY; DOPPLER ultrasonography
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2011, Vol 118, Issue 4, p510
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2010.02794.x