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- Title
First-trimester increase in oxidative stress and risk of small-for-gestational-age fetus.
- Authors
Potdar, N.; Singh, R.; Mistry, V.; Evans, M. D.; Farmer, P. B.; Konje, J. C.; Cooke, M. S.
- Abstract
Objective Investigation of increased oxidative stress in early pregnancy and association with an increased risk of small-for-gestational-age (SGA) fetus. Design Longitudinal case–control study. Setting University Hospitals of Leicester NHS Trust, Leicester, UK. Population Low-risk pregnant women with no current or pre-existing medical illness were recruited at a large teaching hospital from 2004 to 2006. Methods Recruitment performed at the time of the dating ultrasound scan (12 ± 2 weeks of gestation). Spot urine samples collected at 12 ± 2 and 28 ± 2 weeks of gestation were analysed for 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) by liquid chromatography with tandem mass spectrometry). SGA was defined as birthweight <10th centile based on customised centile calculator ( ). This identified the cases ( n= 55), whereas controls ( n= 55) were mothers whose babies were appropriate for gestational age (AGA, birthweight 10th–90th centile). Statistical analysis was performed using GraphPad Prism v.5. The relationship between maternal urinary 8-oxodG at different gestations and customised SGA was investigated by nonparametric tests. Main outcome measures Customised SGA and AGA pregnancies. Results Urinary 8-oxodG concentrations were significantly increased in pregnancies with subsequent SGA compared with concentrations in normal pregnancies; 12 weeks: 2.8 (interquartile range [IQR] 1.96–3.67) versus 2.2 (IQR 1.26–3.28) pmol 8-oxodG/μmol creatinine ( P= 0.0007); 28 weeks: 2.21 (IQR 1.67–3.14) versus 1.68 (IQR 1.16–2.82) pmol 8-oxodG/μmol creatinine ( P < 0.0002). Concentrations decreased significantly between week 12 and 28 ( P= 0.04 and P= 0.02 for controls and cases). Conclusions In this study, urinary 8-oxodG at 12 and 28 weeks were elevated in SGA compared with AGA pregnancies. This may reflect early placental changes predating clinical features of SGA.
- Subjects
LEICESTER (England); ENGLAND; FIRST trimester of pregnancy; PREGNANT women; FETUS; OXIDATIVE stress; LIQUID chromatography; TEACHING hospitals
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2009, Vol 116, Issue 5, p637
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2008.02096.x