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- Title
Influence of Renin Angiotensin System Gene Polymorphisms on Visit-to-Visit Blood Pressure Variability in Hypertensive Patients.
- Authors
Kawai, Tatsuo; Ohishi, Mitsuru; Onishi, Miyuki; Takeya, Yasushi; Ito, Norihisa; Kato, Nozomi; Yamamoto, Koichi; Kamide, Kei; Rakugi, Hiromi
- Abstract
BackgroundVisit-to-visit blood pressure (BP) variability has been reported to be a major risk for cardiovascular events. Renin angiotensin system (RAS) gene polymorphisms are reportedly genetic risk factors for cardiovascular diseases and arterial stiffness. In this study, we aimed to reveal the relationship between visit-to-visit BP variability and RAS gene polymorphisms.MethodsStudy subjects included 427 essential hypertension patients from the Non-Invasive Atherosclerotic Evaluation in Hypertension study cohort, whose BP was measured during at least six outpatient visits. We analyzed the correlation between visit-to-visit variability in systolic BP (SBP) and RAS gene polymorphisms.ResultsWe identified angiotensinogen M235T, angiotensin II type 1 receptor A1166C, and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms. Only ACE I/D polymorphisms were correlated with variability in diastolic BP; no gene polymorphisms were correlated with variability in SBP.ConclusionsRAS gene polymorphisms, especially ACE I/D polymorphisms, might genetically influence the visit-to-visit BP variability in hypertensive patients.American Journal of Hypertension, 2012; doi:10.1038/ajh.2012.118
- Subjects
RENIN-angiotensin system; GENETIC polymorphisms; BLOOD pressure measurement; CARDIOVASCULAR diseases; PATIENTS; SYSTOLIC blood pressure; ANGIOTENSIN converting enzyme
- Publication
American Journal of Hypertension, 2012, Vol 25, Issue 12, p1249
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1038/ajh.2012.118