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- Title
Association of Pre-Chemotherapy Peripheral Blood Pro-Inflammatory and Coagulation Factors with Physical Function inWomen with Breast Cancer.
- Authors
Yuan, Yuan; Vora, Nilesh; Sun, Can-Lan; Li, Daneng; Smith, David; Mortimer, Joanne; Luu, The-Hang; Somlo, George; Waisman, James; Chao, Joseph; Katheria, Vani; Synold, Timothy; Tran, Vivi; Mi, Shu; Feng, Tao; Levi, Abrahm; Arsenyan, Anait; Choi, Jennifer; Zavala, Laura; Yost, Susan
- Abstract
Pro-inflammatory and coagulation factors serve as biomarkers of aging and functional reserve. The purpose of this study was to determine if pro-inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]), and coagulation (D-dimer) factors were associated with pre-chemotherapy functional status in women with stage I-III breast cancer. Patients and Methods. Prior to chemotherapy initiation in patients with stage I-III breast cancer, the following was captured: IL-6, CRP, D-dimer blood levels, and physical function measures including activities of daily living (ADL, subscale of Medical Outcomes Study Physical Health); instrumental activities of daily living (IADL, subscale of the Older Americans Resources and Services Program); Timed Up and Go (TUG); physician-rated Karnofsky Performance Status (KPS); and self-rated KPS. The association of these biomarkers with physical function measures was evaluated. Results. One hundred sixty patients (mean age 58.3 years, range 30-81 years) with stage I-III breast cancer (stages I [n = 34; 21.5%], II [n = 88; 55.7%], III [n = 36; 22.8%]) were enrolled. The group with poorest physical function (defined by ADL <70, IADL <14, and TUG ≥10 seconds) had higher levels of IL-6 (p = .05), D-dimer (p = .0004), and CRP (p = .05). There was no significant association between these biomarkers and KPS. Patients with at least two biomarkers in the highest quartile were more likely to have poorer physical function (odds ration [OR] 18.75, p < .001). In multivariate analysis adjusting for age, stage, number of comorbidities, and body mass index, the association remained (OR 14.6, p = .002). Conclusion. Pre-chemotherapy biomarkers of aging are associated with poorer physical function among patients with breast cancer across the aging spectrum.
- Subjects
BREAST tumor diagnosis; BIOMARKERS; BLOOD; BLOOD coagulation factors; C-reactive protein; CANCER chemotherapy; GERIATRICS; INFLAMMATION; INTERLEUKINS; ONCOLOGY; TUMOR classification; ACTIVITIES of daily living; FIBRIN fibrinogen degradation products; DATA analysis software; FUNCTIONAL assessment
- Publication
Oncologist, 2017, Vol 22, Issue 10, p1189
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2016-0391