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- Title
A case of reversible anti-NMDA-receptor encephalitis: neuropsychological and neuroradiological features.
- Authors
Mutti, Carlotta; Barocco, Federica; Zinno, Lucia; Negrotti, Anna; Spallazzi, Marco; Pavesi, Giovanni; Gardini, Simona; Caffarra, Paolo
- Abstract
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune encephalitis mainly affecting young women. We report a case of a mild paraneoplastic anti-NMDAR encephalitis in a 31-year-old female with an ovarian immature teratoma. The patient exhibited a severe short-term episodic memory impairment and psychiatric symptoms. A detailed diagnostic work-up including complete clinical and laboratory examinations, neuropsychological assessments, and neuroradiological investigations has been done at the onset and during follow-up. The amnestic syndrome and MRI medial-temporal abnormalities reversed after medical and surgical treatment. The present report indicates that the disease can be rapidly reversible if promptly diagnosed and treated. While the disease has already been described elsewhere, the course of neurospychological deficits in adults is not as much known. Usually, when the diagnosis of anti-NMDAR encephalitis is made, the severity of the disease makes the assessment of the neuropsycological profile particulary challenging. The present report is of interest because it describes the complete neuropsychological profile of a mild form of anti-NMDAR encephalitis.
- Subjects
AMNESTIC mild cognitive impairment; ANTI-NMDA receptor encephalitis; HIPPOCAMPUS (Brain); TERATOMA; OVARIAN tumors
- Publication
Neurological Sciences, 2017, Vol 38, Issue 12, p2231
- ISSN
1590-1874
- Publication type
journal article
- DOI
10.1007/s10072-017-3105-4