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- Title
An interesting case of chronic myeloid leukemia (CML) with T315I mutation raising suspicion of de novo AML, a diagnostic conundrum.
- Authors
Iqbal, Phool; Shahzad, Aamir; Shahid, Zubair; Ghori, Firdous; Elomri, Halima; Soliman, Dina
- Abstract
Chronic myeloid leukemia (CML) is a myeloproliferative disorder due to translocation between chromosomes (9, 22), known as the "Philadelphia chromosome." In 2016, the World health organization (WHO) introduced a new clinical entity of de novo acute myeloid leukemia (AML). Both diseases share some commonalities, therefore, create a challenge to diagnose. The differentiation of CML‐BP from de novo AML is crucial in the management of the patient. Therefore, a cautious diagnostic approach involving hematologists and hemato‐histopathologist is required where there is a diagnostic dilemma.
- Subjects
CHRONIC myeloid leukemia; PHILADELPHIA chromosome; ACUTE myeloid leukemia; MYELOPROLIFERATIVE neoplasms; SUSPICION
- Publication
Clinical Case Reports, 2023, Vol 11, Issue 5, p1
- ISSN
2050-0904
- Publication type
Case Study
- DOI
10.1002/ccr3.5908