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- Title
QT Correction Methods in Children and Adolescents.
- Authors
WERNICKE, JOACHIM F.; FARIES, DOUGLAS; BREITUNG, REBECCA; GIROD, DONALD
- Abstract
QT Correction Methods in Children and Adolescents. Introduction:Accurate determination of the QTc interval has become increasingly important in the assessment of a drug's ability to prolong cardiac repolarization. Previous work suggests the most appropriate correction formula for adults is QTc= QT/RR0.40, but little on correction methods for children and adolescents has been published.Methods and Results:In this study, ECG data were obtained from a meta-analysis of seven clinical trials for attention deficit/hyperactivity disorder (ADHD) involving 2,288 children and adolescents. The most appropriate formula for children and adolescents included in this database was found to be QTc= QT/RR0.38. Adjustments of the correction factor specifically for males and females of different ages also are reported.Conclusion:QT correction methods developed for adults do not apply to children. As accurate QTc determination plays a larger role in assessing a drug's potential to retard repolarization, use of age- and gender-specific correction formulas becomes more important.(J Cardiovasc Electrophysiol, Vol. 16, pp. 76-81, January 2005)
- Subjects
ATTENTION-deficit hyperactivity disorder; CLINICAL trials; MEDICAL research; DRUGS; ELECTROCARDIOGRAPHY; PUBLIC health
- Publication
Journal of Cardiovascular Electrophysiology, 2005, Vol 16, Issue 1, p76
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1046/j.1540-8167.2005.03520.x