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- Title
Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
- Authors
Wang, Songyan; Li, Bing; Li, Chunguang; Cui, Wenpeng; Miao, Lining
- Abstract
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. In this review, we only focus on the potential renoprotective therapeutic agents which can specifically abolish CCN2 expression or nonspecifically inhibit CCN2 expression for retarding the development and progression of DN.
- Subjects
DIABETIC nephropathies; CHRONIC kidney failure; CONNECTIVE tissue cells; DRUG efficacy; DISEASE progression; THERAPEUTICS
- Publication
Journal of Diabetes Research, 2015, Vol 2015, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2015/962383