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- Title
Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans.
- Authors
Fadel, Paul J.; Farias III, Martin; Gallagher, Kevin M.; Wang, Zhongyun; Thomas, Gail D.
- Abstract
Non-technical summary Activation of sympathetic nerves decreases blood flow to resting skeletal muscle, but this vasoconstrictor effect normally is blunted during exercise so that blood flow can increase to the working muscles. In rats and humans treated with nitroglycerin for 1 week, we show that overproduction of reactive oxygen species prevents the usual attenuation of sympathetic vasoconstriction in the working muscles, resulting in muscle ischaemia during exercise. Improved knowledge about the effect that reactive oxygen species has on muscle blood flow regulation may help us to better understand the decreased exercise tolerance that occurs with age as well as with chronic disease.
- Subjects
NERVES; SKELETAL muscle; VASOCONSTRICTION; BLOOD flow; NITROGLYCERIN; REACTIVE oxygen species; ISCHEMIA; EXERCISE
- Publication
Journal of Physiology, 2012, Vol 590, Issue 2, p395
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2011.218917