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- Title
Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial.
- Authors
Cheng, Yi‐Kan; Qin, Qi‐Yuan; Huang, Xiao‐Yan; Lan, Ping; Wang, Lei; Gao, Xiang; Ma, Teng‐Hui
- Abstract
Objective: The aim of this study was to evaluate the effect of the interval between CRT and surgery on radiation proctitis, the pathologic response, and postoperative morbidity. Methods: This was a cohort study from a phase III, randomized controlled trial (FOWARC study, NCT01211210). Data were retrieved from the leading center of the trial. Patients were divided into the short‐interval (≤7 weeks) group and the long‐interval (>7 weeks) group. The rate of radiation proctitis, pathologic complete regression (pCR) and morbidities were calculated for each group. Multivariate analysis was used to verify the impact of interval on radiation proctitis. Results: Surgery was performed in 60 patients after an interval of ≤7 weeks and in 97 patients after an interval of >7 weeks. The two groups according to interval were comparable in terms of baseline demographic and clinicotherapeutic characteristics. Radiation proctitis was identified by imaging in 9 (15.0%) patients in short‐interval group and in 31 (32.0%) patients in long‐interval group (P =.018). Multivariate analysis confirmed the correlation between long interval and radiation proctitis (P =.018). The long interval was significantly associated with longer median operation time compared to the short interval (P =.022). The rates of pCR and postoperative complications were not different between two groups. Conclusions: A longer interval after CRT may be associated with higher rate of radiation proctitis and longer operation time. Moreover it did not increase the rate of pCR.
- Subjects
RECTAL cancer; RADIATION; DEMOGRAPHIC characteristics; RECTAL surgery; SURGICAL complications; MULTIVARIATE analysis
- Publication
Cancer Medicine, 2020, Vol 9, Issue 3, p912
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.2755