We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia.
- Authors
Revin, Vistor V.; Gromova, Natalia V.; Revina, Elvira S.; Prosnikova, Ksenia V.; Revina, Nadezhda V.; Bochkareva, Svetlana S.; Stepushkina, Olga G.; Grunyushkin, Igor P.; Tairova, Marina R.; Incina, Vera I.
- Abstract
This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells and altered quantitative and qualitative composition of membrane-skeletal proteins. The findings suggest that hypoxia causes changes at all levels of red blood cell organization, which can cause the functional disorders of hemoglobin oxygen-transporting properties and, eventually, the complete degradation of red blood cells. The use of flavonoids has a protective effect against hypoxia.
- Subjects
ERYTHROCYTES; HYPOXEMIA; CYTOSKELETAL proteins; HEMOGLOBINS; LIPIDS; MEMBRANE proteins; NITROGEN oxides; OXIDATION-reduction reaction; POLYPHENOLS; SODIUM nitroferricyanide; PHARMACODYNAMICS
- Publication
BioMed Research International, 2019, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2019/6758017