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- Title
Bone Augmentation of Peri-Implant Dehiscence Defects Using Multilaminated Small Intestinal Submucosa as a Barrier Membrane: An Experimental Study in Dogs.
- Authors
Siwen Wang; Weiyi Wu; Yuhua Liu; Xinzhi Wang; Lin Tang; Pengyue You; Jianmin Han; Bowen Li; Yi Zhang; Mei Wang
- Abstract
Objective. The aim of the study is to evaluate the effects of multilaminated small intestinal submucosa (mSIS) combined with bone substitute material to repair peri-implant defects during guided bone regeneration procedures. Methods. Twelve implants were placed in bilateral lower premolars of three beagle dogs, and a peri-implant buccal bone defect (3mmwidth and 4mmheight) was created at each implant site. A total of 12 sites were filled with a particulate bone substitute material and then randomly divided into three treatment groups: covered by mSIS membrane (mSIS group), covered by collagen membrane (BG group), and no treatment (control group), each group of four sites. After 12 weeks of healing, all of the animals were euthanized and dissected blocks were obtained for micro-computed tomography (micro-CT) and histological analyses. Results. Micro-CT results revealed similar horizontal width of augmented tissue and new bone formation between mSIS and BG groups (P < 0.05). Histological analyses revealed that the differences in horizontal widths of newly formed bone and bone-to-implant contact between mSIS and BG groups were not significant (P > 0.05). All of these parameters were significantly different from those in the control group (P < 0.05). Conclusions. These findings confirmed that mSIS combined with the bone substitute material enhanced bone regeneration in peri-implant defects, in a manner similar to that of a collagen membrane.
- Subjects
ANIMAL experimentation; BONE substitutes; BONE growth; COLLAGEN; COMPUTED tomography; DOGS; EXPERIMENTAL design; GUIDED tissue regeneration; HISTOLOGICAL techniques; DENTAL implants; INTESTINAL mucosa; ARTIFICIAL membranes; TREATMENT effectiveness; PERI-implantitis; SURGICAL wound dehiscence
- Publication
BioMed Research International, 2019, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2019/8962730