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- Title
Nonneoplastic and neoplastic sclerosing lesions of the breast.
- Authors
Turashvili, Gulisa
- Abstract
Sclerosing lesions of the breast encompass a spectrum of benign and malignant entities and often pose a diagnostic challenge. Awareness of key morphologic features and pitfalls in the assessment of morphology and immunophenotype is essential to avoid over‐ or underdiagnosis and ensure optimal clinical management. This review summarizes nonneoplastic sclerosing lesions such as radial scar/complex sclerosing lesion, sclerosing adenosis, sclerosing intraductal papilloma, sclerosing variants of ductal adenoma and nipple adenoma, and fibroadenoma with extensive sclerosis, including their clinical presentation, characteristic morphology, differential diagnostic considerations, appropriate immunohistochemical work‐up, when needed, and the clinical significance. In addition, atypical or neoplastic entities (such as atypical ductal hyperplasia, ductal carcinoma in situ, low‐grade adenosquamous carcinoma, and fibromatosis‐like metaplastic carcinoma) that can involve these sclerosing lesions are also briefly discussed.
- Subjects
CARCINOMA in situ; SYMPTOMS; DUCTAL carcinoma; ADENOMA; PAPILLOMA; BREAST
- Publication
Histopathology, 2024, Vol 85, Issue 3, p383
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.15252