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- Title
Accurate SARC-F Score in Patients with Liver Disease.
- Authors
Matsui, Masahiro; Asai, Akira; Ushiro, Kosuke; Onishi, Saori; Nishikawa, Tomohiro; Yokohama, Keisuke; Ohama, Hideko; Tsuchimoto, Yusuke; Kim, Soo Ki; Nishikawa, Hiroki
- Abstract
SARC-F is a well-accepted screening tool for sarcopenia. A SARC-F value of 1 point is reported to be more discriminating in identifying sarcopenia than 4 points (recommended cutoff point). The prognostic impact of the SARC-F score was investigated in patients with liver disease (LD, n = 269, median age = 71 years, 96 hepatocellular carcinoma (HCC) cases). Factors associated with SARC-F ≥ 4 points and SARC-F ≥ 1 point were also examined. In the multivariate analysis, age (p = 0.048), and Geriatric Nutritional Risk Index (GNRI) score (p = 0.0365) were significant factors linked to SARC-F ≥ 1 point. In our patients with LD, the SARC-F score is well correlated with the GNRI score. The 1-year cumulative overall survival ratio in patients with SARC-F ≥ 1 (n = 159) and SARC-F 0 (n = 110) was 78.3% and 90.1% (p = 0.0181). After excluding 96 HCC cases, similar tendencies were found (p = 0.0289). In the receiver operating curve (ROC) analysis based on the prognosis for the SARC-F score, the area under the ROC was 0.60. The sensitivity was 0.57, the specificity was 0.62, and the optimal cutoff point of the SARC-F score was 1. In conclusion, sarcopenia in LDs can be affected by nutritional conditions. A SARC-F score of ≥1 is more useful than a score of 4 in predicting the prognosis of patients with LD.
- Subjects
LIVER diseases; SARCOPENIA; OVERALL survival; MULTIVARIATE analysis; HEPATOCELLULAR carcinoma
- Publication
Diagnostics (2075-4418), 2023, Vol 13, Issue 11, p1959
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics13111959