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- Title
Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies.
- Authors
Issa, Amudalat; Abdulkadir, Mohammed; Ibraheem, Rasheedat; Ibrahim, Olayinka; Bello, Surajudeen; Suberu, Habibat; Sanusi, Ibraheem
- Abstract
Background: A proper evaluation of cardiovascular status, with a view to ensuring early diagnosis of cardiac dysfunction and prompt intervention where necessary, is a recognized approach in the management of asphyxiated neonates. Hence, we determined the levels of a cardiac biomarker (troponin I), its relationship with disease severity, and mortality in asphyxiated neonates with hypoxic–ischemic encephalopathy (HIE). Methods: This was a descriptive study that involved 85 asphyxiated, term appropriate-for-gestational age newborn babies with HIE (subjects) and 85 healthy controls within the first 72 h of life. Asphyxiated neonates were classified into HIE stages using Sarnat and Sarnat staging. Blood samples were collected between 24 and 72 h of life to determine the level of troponin I using enzyme-linked immunosorbent assay. The asphyxiated babies were followed up till discharge or death. Results: The median interquartile range level of troponin I in the subjects was higher compared with the controls, 1.26 (0.97–3.16) ng/ml versus 0.79 (0.79–1.42) ng/ml, P < 0. 001. The levels of troponin I in HIE I, HIE II, and HIE III were 1.26 (1.00–2.37) ng/ml, 1.11 (0.86–2.96) ng/ml, and 3.58 (1.34–5.58) ng/ml, respectively. Nonsurvivors had a higher cardiac troponin I (4.00 [2.30–6.34] ng/ml) compared with survivors (1.21 [0.95–2.37] ng/ml), P = 0.015. Conclusion: Cardiac troponin I was significantly higher in asphyxiated subjects compared with healthy controls. Elevated troponin I was associated with higher mortality. Troponin I levels in the first 72 h can help as a prognostic indicator of HIE in term babies.
- Subjects
TROPONIN I; NEWBORN infants; ENZYME-linked immunosorbent assay; INFANTS; BIOMARKERS
- Publication
Journal of Clinical Neonatology, 2021, Vol 10, Issue 3, p187
- ISSN
2249-4847
- Publication type
Article
- DOI
10.4103/jcn.jcn_179_20