We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Marked differences in Betapapillomavirus DNA and antibody prevalence between patients with psoriasis and those with atopic dermatitis.
- Authors
de Koning, M. N. C.; Polderman, M. C. A.; Waterboer, T.; ter Schegget, J.; Feltkamp, M.C.W.; Pawlita, M.; Bouwes Bavinck, J. N.; Quint, W. G. V.
- Abstract
Recent studies revealed that Betapapillomavirus (betaPV) infections are highly prevalent. Skin diseases such as psoriasis, characterized by keratinocyte hyperproliferation, and atopic dermatitis (AD), dominated by cutaneous inflammation, might have an impact on viral life cycle and immune response induction. To investigate whether betaPV infection is different in psoriasis and AD. Twenty-seven patients with psoriasis and 17 with AD were included for betaPV genotyping using eyebrow hairs, and for seroresponse determination. BetaPV DNA was found significantly more often in patients with psoriasis than in those with AD (100% vs. 81%, P = 0·022) and the mean number of betaPV types was higher (4·8 vs. 2·1 types, P = 0·002). In contrast, the seroprevalence in patients with AD was significantly higher compared with that in patients with psoriasis (88% vs. 56%, P = 0·023). Type-specific concordance of serological response to the betaPV type detected in eyebrow hairs was 27% in patients with psoriasis and 47% in those with AD ( P = 0·019). We speculate that the condition of the skin and the immunological state of the patients have an important impact on the life cycle of betaPV.
- Subjects
PAPILLOMAVIRUSES; DISEASE prevalence; KERATINOCYTES; IMMUNE response; PSORIASIS; ATOPIC dermatitis; PATIENTS
- Publication
British Journal of Dermatology, 2011, Vol 164, Issue 4, p771
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.2010.10182.x