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- Title
A multicenter, open-label study for efficacy and safety evaluation of anagrelide in patients with treatmentnaïve, high-risk essential thrombocythemia as a primary treatment.
- Authors
Ja Min Byun; Ho Young Kim; Seung-Hyun Nam; Ho-Jin Shin; Seulki Song; Jinny Park; Sang Hoon Han; Yong Park; Young Jin Yuh; Yeung-Chul Mun; Young Rok Do; Sang Kyun Sohn; Sung Hwa Bae; Dong-Yeop Shin; Sung-Soo Yoon
- Abstract
As the discussion of first-line anagrelide treatment is ongoing, we aimed to prospectively examine the efficacy and safety of anagrelide in cytoreduction therapy-naïve high risk essential thrombocythemia (ET) patients in Korea. Seventy patients from 12 centers were treated with anagrelide monotherapy for up to 8 weeks, followed up until 24 months. At week 8, 50.0% of the patients were able to achieve platelet < 600 x 109/L, and by 12 months, 55/70 (78.6%) patients stayed on anagrelide, and 40.0% patients showed platelet normalization. 14 patients required additional hydroxyurea (HU) for cytoreduction. The median daily dose of needed HU was 500mg (range 250mg -- 1500mg). The efficacy was independent of the somatic mutation status. There were 4 thromboembolic events and 7 bleeding events during the follow-up period. The most common adverse events associated with anagrelide use were headache, followed by palpitation/chest discomfort, edema and generalized weakness/fatigue. 7 patients wished to discontinue anagrelide treatment due to adverse events (3 due to headache; 2 due to edema; 1 due to palpitation and 1 due to skin eruption). All in all, first-line anagrelide treatment showed a favorable response with tolerable safety profiles regardless of somatic mutation status.
- Subjects
SOUTH Korea; THROMBOCYTOSIS; SOMATIC mutation; PALPITATION
- Publication
Frontiers in Oncology, 2022, Vol 12, p01
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.989984