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- Title
mir-146a and mir-155 expression levels in acute graft-Versus-host Disease incidence.
- Authors
Atarod, Sadaf; Ahmed, Mohammed Mahid; Lendrem, Clare; Pearce, Kim Frances; Cope, Wei; Norden, Jean; Xiao-Nong Wang; Collin, Matthew; Dickinson, Anne Mary; Spierings, Eric
- Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.
- Subjects
HEMATOPOIETIC stem cell transplantation; HEMATOLOGIC malignancies; GRAFT versus host disease; THERAPEUTICS
- Publication
Frontiers in Immunology, 2016, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00056