We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Review Calcium sensors as new therapeutic targets for asthma and chronic obstructive pulmonary disease.
- Authors
Broeke, R. Ten; Blalock, J. E.; Nijkamp, F. P.; Folkerts, G.
- Abstract
Airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway hyper responsiveness, epithelial damage, oxidative stress and airway inflammation. Although new therapeutic approaches, such as, anti-leukotrienes, and immunotherapy have been developed, new insights into the pathophysiology of these diseases might lead to effective therapeutic targets for the treatment of asthma and COPD. Indeed, the regulation of intracellular calcium may play a crucial role in the pathogenesis because an increase in the intracellular calcium concentration is an essential initiating mechanism of cellular activation in several cells involved in these airway diseases.
- Subjects
CALCIUM; ASTHMA; OBSTRUCTIVE lung diseases; OXIDATIVE stress; PATHOLOGICAL physiology; THERAPEUTICS
- Publication
Clinical & Experimental Allergy, 2004, Vol 34, Issue 2, p170
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/j.1365-2222.2004.01908.x