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- Title
A genome-wide survey of human short-term memory.
- Authors
Papassotiropoulos, A.; Henke, K.; Stefanova, E.; Aerni, A.; Müller, A.; Demougin, P.; Vogler, C.; Sigmund, J. C.; Gschwind, L.; Huynh, K.-D.; Coluccia, D.; Mondadon, C. R.; Hänggi, J.; Buchmann, A.; Kostic, V.; Novakovic, I.; van den Bussche, H.; Kaduszkiewicz, H.; Weyerer, S.; Bickel, H.
- Abstract
Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909 622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the α subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory.
- Subjects
SHORT-term memory; GENOMICS; NEUROBEHAVIORAL disorders; SCHIZOPHRENIA; MENTAL depression; HUMAN genetic variation; GENETIC polymorphisms; MAGNETIC resonance imaging
- Publication
Molecular Psychiatry, 2011, Vol 16, Issue 2, p184
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/mp.2009.133