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- Title
Development of selective bispecific Wnt mimetics for bone loss and repair.
- Authors
Fowler, Tristan W.; Mitchell, Troy L.; Janda, Claudia Y.; Xie, Liqin; Tu, Shengjiang; Chen, Hui; Zhang, Haili; Ye, Jingjing; Ouyang, Brian; Yuan, Tom Z.; Lee, Sung-Jin; Newman, Maureen; Tripuraneni, Nikita; Rego, Erica S.; Mutha, Devin; Dilip, Archana; Vuppalapaty, Meghah; Baribault, Helene; Yeh, Wen-Chen; Li, Yang
- Abstract
The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this platform, we engineer bi-specific Wnt mimetics that target Frizzled and low-density lipoprotein receptor-related proteins and evaluate their effects on bone accrual in murine models. These synthetic Wnt agonists induce rapid and robust bone building effects, and correct bone mass deficiency and bone defects in various disease models, including osteoporosis, aging, and long bone fracture. Furthermore, when these Wnt agonists are combined with antiresorptive bisphosphonates or anti-sclerostin antibody therapies, additional bone accrual/maintenance effects are observed compared to monotherapy, which could benefit individuals with severe and/or acute bone-building deficiencies. Our data support the continued development of Wnt mimetics for the treatment of diseases of low bone mineral density, including osteoporosis. Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when administered after fracture.
- Subjects
BONE density; WNT signal transduction; THERAPEUTICS; BONE fractures; BONE diseases
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-23374-8