We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement.
- Authors
Ariaee, Nazila; Zarei, Shima; Mohamadi, Mojgan; Jabbari, Farahzad
- Abstract
Background: Spontaneous urticaria is a common allergic skin condition affecting 0.5--1% of individuals and may burden on health care expenditure or may be associated with remarkable morbidity. Aim: In this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Furthermore, quality of life and cytokine changes were evaluated. Methods: The clinical trial was conducted on 20 patients with idiopathic chronic urticaria. Vitamin D was administered orally for 8 weeks and disease activity was measured pre- and post-treatment using USS and DLQI. On the other hand expressions of IL-17, IL-10, Foxp3, and TGF-β by Real-time RT-PCR were assessed. Results: USS questionnaire showed that severity of idiopathic urticaria after the intervention, which compared with the first day reached a significant 55% reduction. The DLQI quality of life questionnaire 2 months after treatment showed 55% improvement. Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant. Limitation: These might happen due to lack of enrolled population in the investigation. Conclusion: Vitamin D can be used along with standard medical care and it's a safe and cost-effective method for the treatment of chronic urticaria with deficiency of vitamin D.
- Subjects
THERAPEUTIC use of vitamin D; CHRONIC diseases; CLINICAL trials; CYTOKINES; DIETARY supplements; GENE expression; INTERLEUKINS; MEDICAL care; ORAL drug administration; POLYMERASE chain reaction; QUALITY of life; QUESTIONNAIRES; T cells; TRANSCRIPTION factors; TRANSFORMING growth factors-beta; URTICARIA; VITAMIN D deficiency; SEVERITY of illness index; REVERSE transcriptase polymerase chain reaction
- Publication
Clinical & Molecular Allergy, 2017, Vol 15, p1
- ISSN
1476-7961
- Publication type
Article
- DOI
10.1186/s12948-017-0078-z