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- Title
Manganese-doped mesoporous polydopamine nanoagent for T1–T2 magnetic resonance imaging and tumor therapy.
- Authors
Hou, Xiuqi; Yang, Xi; Xu, Yanwen; Lin, Jiayin; Zhang, Fang; Duan, Xiaohui; Liu, Sitong; Liu, Jie; Shen, Jun; Shuai, Xintao; Cao, Zhong
- Abstract
Theranostic nanodrugs combining magnetic resonance imaging (MRI) and cancer therapy have attracted extensive interest in cancer diagnosis and treatment. Herein, a manganese (Mn)-doped mesoporous polydopamine (Mn-MPDA) nanodrug incorporating the nitric oxide (NO) prodrug BNN6 and immune agonist R848 was developed. The nanodrug responded to the H+ and glutathione being enriched in tumor microenvironment to release R848 and Mn2+. The abundant Mn2+ produced through a Fenton-like reaction enabled a highly sensitive T1–T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug, based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy. Meanwhile, R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype. Consequently, a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer, which manifested the great promise of this multifunctional nanoplatform in cancer treatment.
- Subjects
MAGNETIC resonance imaging; BREAST cancer treatment; MESOPOROUS materials; PHENOTYPES; MACROPHAGES
- Publication
Nano Research, 2023, Vol 16, Issue 2, p2991
- ISSN
1998-0124
- Publication type
Article
- DOI
10.1007/s12274-022-4877-4