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- Title
Aptamer-Based Biosensing with a Cationic AIEgen*.
- Authors
Luu, Tracey; Liu, Mengjie; Chen, Yilong; Hushiarian, Roozbeh; Cass, Anthony; Tang, Ben Zhong; Hong, Yuning
- Abstract
Fabrication of low-cost biosensing platforms with high selectivity and sensitivity is important for constructing portable devices for personal health monitoring. Herein, we report a simple biosensing strategy based on the combination of a cationic AIEgen (aggregation-induced emission fluorogen), TPE-2+, with an aptamer for specific protein detection. The target protein can displace the dye molecules on the dye–aptamer complex, resulting in changes in the fluorescence signal. Selectivity towards different targets can be achieved by simply changing the aptamer sequence. The working mechanism is also investigated. Specific detection of proteins can be achieved by using a complex of aptamer and cationic aggregation-induced emission fluorogen.
- Subjects
ONLINE monitoring systems; DIPYRRINS; FLUORESCENCE
- Publication
Australian Journal of Chemistry, 2019, Vol 72, Issue 8, p620
- ISSN
0004-9425
- Publication type
Article
- DOI
10.1071/CH19238