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- Title
Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease.
- Authors
Donix, Markus; Scharf, Maria; Marschner, Kira; Werner, Annett; Sauer, Cathrin; Gerner, Antje; Nees, Josef A.; Meyer, Shirin; Donix, Katharina L.; Rüdiger Von Kummer; Holthoff1,2, Vjera A.
- Abstract
Cardiovascular risk factors influence onset and progression of Alzheimer's disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In patients with Alzheimer's disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory. We wanted to investigate whether this regional cortical thinningwould be modulated by cardiovascular risk factors.We utilized high-resolutionmagnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer's disease. Cardiovascular risk was assessed using a sex-specific multivariable risk score. Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2/3/dentate gyrus area but not other hippocampal and medial temporal subregions. APOE genotype, a family history of Alzheimer's disease, and age did not influence cortical thickness. Alzheimer's disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable. This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer's disease.
- Subjects
HIPPOCAMPUS (Brain); ALZHEIMER'S disease; CARDIOVASCULAR diseases risk factors; GOODNESS-of-fit tests; MAGNETIC resonance imaging; MULTIVARIATE analysis; REGRESSION analysis; STATISTICS; DATA analysis; DESCRIPTIVE statistics; DISEASE complications; ANATOMY
- Publication
International Journal of Alzheimer's Disease, 2013, p1
- ISSN
2090-0252
- Publication type
Article
- DOI
10.1155/2013/108021