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- Title
<i>p21</i> rs3176352 G>C and <i>p73</i> rs1801173 C>T Polymorphisms Are Associated with an Increased Risk of Esophageal Cancer in a Chinese Population.
- Authors
Zheng, Liang; Tang, Weifeng; Shi, Yijun; Chen, Suocheng; Wang, Xu; Wang, Liming; Shao, Aizhong; Ding, Guowen; Liu, Chao; Liu, Ruiping; Yin, Jun; Gu, Haiyong
- Abstract
Objective: Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis. Designs and Methods: To evaluate the effect p21, p53, TP53BP1 and p73 single nucleotide polymorphisms (SNPs) on the risk of ESCC, we conducted a hospital based case–control study. A total of 629 ESCC cases and 686 controls were recruited. Their genotypes were determined using ligation detection reaction (LDR) method. Results: When the p21 rs3176352 GG homozygote genotype was used as the reference group, the CC genotype was associated with a significantly increased risk of ESCC. When the p73 rs1801173 CC homozygote genotype was used as the reference group, the CT genotype was associated with a significantly increased risk of ESCC. After Bonferroni correction, for p21 rs3176352 G>C, the pcorrect was still significant. For the other six SNPs, in all comparison models, no association between the polymorphisms and ESCC risk was observed. Conclusions: p21 rs3176352 G>C and p73 rs1801173 C>T SNPs are associated with increased risk of ESCC. To confirm the current findings, additional, larger studies and tissue-specific biological characterization are required.
- Subjects
DIAGNOSIS of esophageal cancer; GENETIC polymorphisms; CANCER-related mortality; SQUAMOUS cell carcinoma; SINGLE nucleotide polymorphisms; CANCER prevention
- Publication
PLoS ONE, 2014, Vol 9, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0096958