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- Title
Weight Gain Is Associated with Medial Contact Site of Subthalamic Stimulation in Parkinson's Disease.
- Authors
Růžička, Filip; Jech, Robert; Novákova, Lucie; Urgošík, Dušan; Vymazal, Josef; Růžička, Evžen
- Abstract
The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson's disease rating scale (UPDRS-III) was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r =20.55, p,0.01) and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r =20.42, p<0.01). Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4±(SD)4.4 kg, N = 11) than those with both contacts located laterally (3.9±2.7 kg, N = 9) (p<0.001). The position of the active contact is critical not only for motor outcome but is also associated with weight gain, suggesting a regional effect of subthalamic stimulation on adjacent structures involved in the central regulation of energy balance, food intake or reward.
- Subjects
BODY weight; WEIGHT gain; PARKINSON'S disease; BODY composition; MAGNETIC resonance imaging; MOTOR ability
- Publication
PLoS ONE, 2012, Vol 7, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0038020