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- Title
Phenotyping mice with skin, hair, or nail abnormalities: A systematic approach and methodologies from simple to complex.
- Authors
Sundberg, John P.; Rice, Robert H.
- Abstract
The skin and adnexa can be difficult to interpret because they change dramatically with the hair cycle throughout life. However, a variety of methods are commonly available to collect skin and perform assays that can be useful for figuring out morphological and molecular changes. This overview provides information on basic approaches to evaluate skin and its molecular phenotype, with references for more detail, and interpretation of results on the skin and adnexa in the mouse. These approaches range from mouse genetic nomenclature, setting up a cutaneous phenotyping study, skin grafts, hair follicle reconstitution, wax stripping, electron microscopy, and Köbner reaction to very specific approaches such as lipid and protein analyses on a large scale.
- Subjects
SKIN grafting; LIPID analysis; HAIR; PROTEIN analysis; ELECTRON microscopy; HAIR follicles
- Publication
Veterinary Pathology, 2023, Vol 60, Issue 6, p829
- ISSN
0300-9858
- Publication type
Article
- DOI
10.1177/03009858231170329