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- Title
Eosinophil-to-Monocyte Ratio is a Potential Predictor of Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.
- Authors
Chen, Yueping; Ren, Junli; Yang, Naiping; Huang, Honghao; Hu, Xueting; Sun, Fangyue; Zeng, Tian; Zhou, Xinbo; Pan, Wenjing; Hu, Jingyu; Gao, Beibei; Zhang, Shunkai; Chen, Guangyong
- Abstract
Background: Eosinophil and monocyte have been demonstrated separately to be independent predictors of acute ischemic stroke (AIS). This study aimed to evaluate the association between eosinophil-to-monocyte ratio (EMR) and 3-month clinical outcome after treatment with recombinant tissue plasminogen activator (rt-PA) for AIS patients. Simultaneously, we made a simple comparison with other prognostic indicators, such as 24h neutrophil-to-lymphocyte ratio (NLR) and 24h platelet-to-lymphocyte ratio (PLR) to investigate the prognostic value of EMR. Methods and Results: A total of 280 AIS patients receiving intravenous thrombolysis were retrospectively recruited for this study. Complete blood count evaluations for EMR were conducted on 24 hours admission. The poor outcome at 3-month was defined as the modified Rankin Scale (mRS) of 3– 6 and the mRS score for death was 6. The EMR levels in patients with AIS were lower than those in the healthy controls and showed a negative correlation with the NIHSS score. At the 3-month follow-up, multivariate logistic regression analysis indicated an association among EMR, poor outcome and mortality. In addition, EMR had a higher predictive ability than popular biomarkers like NLR and PLR for 3-month mortality. Conclusion: The lower levels of EMR were independently associated with poor outcome and dead status in AIS patients.
- Subjects
STROKE patients; STROKE; ADOLESCENT idiopathic scoliosis; ISCHEMIC stroke; TISSUE plasminogen activator; BLOOD cell count; PROGNOSIS
- Publication
Clinical Interventions in Aging, 2021, Vol 16, p853
- ISSN
1178-1998
- Publication type
Article
- DOI
10.2147/CIA.S309923