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- Title
The effect of replacing aluminium hydroxide with calcium acetate/magnesium carbonate on serum phosphorus control in haemodialysis patients.
- Authors
Arroyo, David; Panizo, Nayara; Abad, Soraya; Vega, Almudena; José, Ana Pérez-de; López-Gómez, Juan M.
- Abstract
Introduction: Calcium acetate/magnesium carbonate (MgCO3) is a phosphorus binder with advantages in terms of cost, safety and tolerance and it has a similar efficacy to other drugs. The objective of the study is to assess the effects of replacing aluminium hydroxide [Al(OH3)] with MgCO3 on phosphorus and calcium metabolism in a cohort of haemodialysis patients. Materials and methods: We included 21 patients with phosphorus <5mg/dl, with Al(OH3) as the only binder. The conversion to MgCO3 was carried out without changing the number of pills. We recorded clinical-demographic characteristics, treatment for secondary hyperparathyroidism and laboratory parameters before conversion and every month for four months. Results: Phosphataemia decreased from 4.52±0.99 to 4.02±1.07mg/ dl (P=.027), and there was a decrease in the calcium-phosphorus product from 40.20±10.44 to 35.16±11.06mg2/dl2 (P=.037). We did not observe significant changes in levels of calcium, parathyroid hormone or 25-OH-vitamin D3. The daily number of pills prescribed was reduced from 3.33±2.29 to 2.15±2.21 (P=.020). Concomitant treatments were not altered. We observed an initial significant increase in magnesaemia from 2.21±0.24 to 2.43±0.39mg/ dl (P=.001), which subsequently remained stable. We found a decrease in serum aluminium from 14.91±8.55 to 8.47±3.98μg/l (P=.004), with levels within the recommended range in all patients. Conclusions: MgCO3 allowed good control of serum phosphorus in haemodialysis patients who were previously well controlled with Al(OH)3, using fewer daily pills. There was a slight increase in serum magnesium, without short-term clinical significance. We do not know the effects of this increase in the longer term.
- Subjects
CALCIUM acetate; MAGNESIUM carbonate; HEMODIALYSIS patients; DRUG efficacy; CALCIUM metabolism disorders
- Publication
Nefrologia, 2014, Vol 34, Issue 2, p199
- ISSN
0211-6995
- Publication type
Article
- DOI
10.3265/Nefrologia.pre2013.Nov.12145