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- Title
Creation of an Esophageal Atresia Animal Model Using a Bifurcated Esophagus to Maintain Digestive Tract Continuity.
- Authors
Glenn, Ian C.; Bruns, Nicholas E.; Schomisch, Steve J.; Ponsky, Todd A.
- Abstract
<bold>Introduction: </bold>We previously developed a porcine model of long gap pure esophageal atresia (EA) to aid in the creation of novel devices and techniques for treatment of EA. Shortcomings of the model included difficulty decompressing the proximal esophageal pouch (leading to recurrent aspiration) and a requirement for gastrostomy tube (G-tube) feeds. Therefore, we sought to create a porcine model with a bifurcated esophagus wherein one portion of the esophageal lumen retained patency and the other part mimicked EA.<bold>Methods: </bold>After G-tube placement, thoracotomy was performed with subsequent partial stapled transection of the esophagus in a transverse manner, followed by longitudinal, partial stapled transection of the esophagus proximally and distally. Magnets were placed in the esophageal pouches.<bold>Results: </bold>Proximal and distal esophageal pouches were created while preserving a parallel, narrower segment of continuous esophagus. G-tube feeds were used initially, but the animal ultimately tolerated full nutrition by mouth. The magnets successfully restored esophageal continuity. The animal regained much of the initial weight lost and survived to planned euthanasia. Necropsy revealed anastomosis formation without evidence of leak.<bold>Conclusions: </bold>A bifurcated porcine esophagus model was successfully devised, simulating EA while allowing the animal to receive oral feeds and clear oral secretions. This model is anticipated to promote animal well-being and ease of care during future investigations, as well as a platform for the safe development of new therapies for EA.
- Subjects
ESOPHAGEAL atresia; GASTROSTOMY; THORACOTOMY; ESOPHAGEAL abnormalities; AUTOPSY; ESOPHAGEAL surgery; ANIMALS; BIOLOGICAL models; ENDOSCOPY; ENTERAL feeding; ESOPHAGEAL diverticula; FLUOROSCOPY; SWINE; SURGICAL anastomosis
- Publication
Journal of Laparoendoscopic & Advanced Surgical Techniques, 2017, Vol 27, Issue 10, p1079
- ISSN
1092-6429
- Publication type
journal article
- DOI
10.1089/lap.2017.0180