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- Title
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart.
- Authors
Ortiz, Vanessa Duarte; Teixeira, Rayane Brinck; Türck, Patrick; Corssac, Giana Blume; Belló-Klein, Adriane; de Castro, Alexandre Luz; Araujo, Alex Sander da Rosa
- Abstract
Inflammatory pathways of Toll-like receptor 4 (TLR4) and NLRP3 inflammasome contribute to acute myocardial infarction (AMI) pathophysiology. The hypoxia‐inducible factor 1α (HIF-1α), however, is a key transcription factor related to cardioprotection. This study aimed to compare the influence of carvedilol and thyroid hormones (TH) on inflammatory and HIF-1α proteins and on cardiac haemodynamics in the infarcted heart. Male Wistar rats were allocated into five groups: sham-operated group (SHAM), infarcted group (MI), infarcted treated with the carvedilol group (MI + C), infarcted treated with the TH group (MI + TH), and infarcted co-treated with the carvedilol and TH group (MI + C + TH). Haemodynamic analysis was assessed 15 days post-AMI. The left ventricle (LV) was collected for morphometric and Western blot analysis. The MI group presented LV systolic pressure reduction, LV end-diastolic pressure elevation, and contractility index decrease compared to the SHAM group. The MI + C, MI + TH, and MI + C + TH groups did not reveal such alterations compared to the SHAM group. The MI + TH and MI + C + TH groups presented reduced MyD88 and NLRP3 and increased HIF-1α levels. In conclusion, all treatments preserve the cardiac haemodynamic, and only TH, as isolated treatment or in co-treatment with carvedilol, was able to reduce MyD88 and NLRP3 and increase HIF-1α in the infarcted heart.
- Subjects
THYROID hormone receptors; CARVEDILOL; THYROID hormones; PROTEIN hormones; MYOCARDIAL infarction; WESTERN immunoblotting; CONTRACTILE proteins
- Publication
Canadian Journal of Physiology & Pharmacology, 2023, Vol 101, Issue 2, p106
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2022-0355