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- Title
Effects of Intravenous Zoledronic Acid Once Yearly on Bone Remodeling and Bone Structure.
- Authors
Reeker, Robert R.; Delmas, Pierre D.; Halse, Johan; Reid, Ian R.; Boonen, Steven; Garcia-Hernandez, Pedro A.; Supronik, Jerzy; Lewiecki, E. Michael; Ochoa, Luis; Miller, Paul; Huilin Hu; Mesenbrink, Peter; Hartl, Florian; Gasser, Juerg; Eriksen, Erik F.
- Abstract
The article presents a case study that examines the effects of intravenous zoledronic acid on bone remodeling and bone structure. About 5 milligrams of zoledronic acid lowered the risk of fractures in patients with postmenopausal osteoporosis. It also decreased bone turnover by 63% and preserved bone structure and volume with bone remodeling in 99% of biopsies. Patients showed higher trabecular bone volume and numbers with a decreased trabecular separation and bone formation rate (BFR).
- Subjects
BONE remodeling; INTRAVENOUS injections; DIPHOSPHONATES; BONE growth; OSTEOPOROSIS in women; CASE studies
- Publication
Journal of Bone & Mineral Research, 2008, Vol 23, Issue 1, p6
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.070906