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- Title
Comment on: Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia.
- Authors
Sheehan, Vivien A.; van Beers, Eduard J.; Connes, Philippe; van Wijk, Richard; Rab, Minke A. E.
- Abstract
Keywords: hydroxycarbamide; oxygen gradient ektacytometry; red blood cell deformability; sickle cell anaemia; -thalassaemia EN hydroxycarbamide oxygen gradient ektacytometry red blood cell deformability sickle cell anaemia -thalassaemia e61 e62 2 05/31/22 20220601 NES 220601 We read with great interest the recently published report of Nardo-Marino I et al i .1 The authors report results of a study designed to: (1) investigate the relationship between oxygen gradient ektacytometry-derived biomarkers and two established markers of disease severity in children with sickle cell anaemia (SCA), (2) examine the impact of hydroxycarbamide (hydroxyurea [HU]) on red blood cell (RBC) deformability measured with oxygen gradient ektacytometry and (3) investigate the ability of oxygen gradient ektacytometry-derived parameters to predict pain as a clinical outcome in SCA. This pain crisis could be explained by the distribution of HbF or other RBC characteristics that can be captured by oxygen gradient ektacytometry and other functional biomarkers such as blood viscosity and that is also dependent on multiple factors including RBC characteristics.
- Subjects
SICKLE cell anemia; OXYGEN
- Publication
British Journal of Haematology, 2022, Vol 197, Issue 5, pe61
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18069