We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The landscape of genetic mutations in patients with chronic lymphocytic leukaemia and complex karyotype.
- Authors
Strati, Paolo; Wang, Feng; Tambaro, Francesco P.; Thompson, Philip A.; Burger, Jan A.; Jain, Nitin; Ferrajoli, Alessandra; Bose, Prithviraj; Estrov, Zeev; Keating, Michael J.; Futreal, Andrew; Takahashi, Koichi; Wierda, William G.
- Abstract
Stimulated conventional metaphase karyotype (CMK) is a reliable method to identify complex karyotype (CK), which has been associated with an unfavourable prognosis in patients with chronic lymphocytic leukaemia (CLL) (Thompson et al, [10]). Patient baseline characteristics at time of gene mutation testing among 71 patients with CK and in a control group of 90 patients without CK, cared for during the same time range. When limiting the analysis to the 89 patients with treatment-naïve CLL, the 34 patients with CK (including high CK), had a significantly higher prevalence of mutated TP53 (29% vs. 7%, P = 0-008). When comparing the 43 patients with high CK to the 118 patients without high CK, only the association with mutated TP53 was maintained (42% vs. 13%, P < 0-001) (Fig A; Data S1).
- Subjects
LEUKEMIA; CHRONIC lymphocytic leukemia; LYMPHOCYTOSIS
- Publication
British Journal of Haematology, 2019, Vol 187, Issue 1, pe1
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.16117