We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan: the Japan Public Health Centre-based Prospective Study.
- Authors
Ugai, Tomotaka; Matsuo, Keitaro; Sawada, Norie; Iwasaki, Motoki; Yamaji, Taiki; Shimazu, Taichi; Sasazuki, Shizuka; Inoue, Manami; Kanda, Yoshinobu; Tsugane, Shoichiro; Hanaoka, T.; Ogata, J.; Baba, S.; Mannami, T.; Okayama, A.; Kokubo, Y.; Miyakawa, K.; Saito, F.; Koizumi, A.; Sano, Y.
- Abstract
Smoking and alcohol are important modifiable risk factors for human cancers. However, few epidemiological studies have investigated their association with the risk of myelodysplastic syndromes ( MDS). Here, we investigated the association of smoking and alcohol consumption and the risk of MDS in a large-scale population-based cohort study in Japan. We included 95 510 Japanese subjects (45 451 men and 50 059 women; age 40-69 years at baseline) and identified 70 MDS cases (50 men and 20 women) during 18·3 years of follow-up. Hazard ratios ( HRs) and 95% confidence intervals (95% CI) were estimated using a Cox regression model adjusted for potential confounders. Smoking was marginally associated with an increased risk of MDS among men, with a HR for current smokers relative to never smokers of 2·11 (95% CI: 0·91-4·89). In contrast, alcohol consumption was associated with a dose-dependent decrease in the risk of MDS among men (nondrinkers: reference, occasional drinkers: HR = 0·48, 0·16-1·41; 0-299 g/week: HR = 0·37, 0·19-0·73; ≥300 g/week: HR = 0·49, 0·22-1·08, P for trend = 0·010). This study showed that alcohol has a significant protective effect on the risk of MDS. In addition, this study might indicate that smoking increases the risk of MDS among Japanese population, as it does in Western populations.
- Subjects
JAPAN; PUBLIC health research; PUBLIC health; MYELODYSPLASTIC syndromes; SMOKING; ALCOHOL drinking; DISEASE risk factors
- Publication
British Journal of Haematology, 2017, Vol 178, Issue 5, p747
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.14749