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- Title
Community and individual iodine status assessment in premenopausal women in Shanxi, China: Repeated spot urine versus 24-hour urine.
- Authors
Xiaomin Jia; Jie Liu; Wenwen Gu; Peng Zhang; Wendi Liu; Hong Zhu; Xiaotong Liu; Maocheng Sang; Jiawen Ding; Zhongna Sang; Jia, Xiaomin; Liu, Jie; Gu, Wenwen; Zhang, Peng; Liu, Wendi; Zhu, Hong; Liu, Xiaotong; Sang, Maocheng; Ding, Jiawen; Sang, Zhongna
- Abstract
<bold>Background and Objectives: </bold>Urinary iodine is an essential index of iodine nutrition evaluation. To establish the number of repeated spot urine collections necessary to reflect individual iodine status over 2 months and assess its feasibility to serve as an independent indicator of individual iodine status.<bold>Methods and Study Design: </bold>We performed a longitudinal, 2-months study from May to June in 2015 of 23 apparently healthy Chinese women aged 18 to 44 (32±9) y. Spot urine samples were collected on any two days of the week, and 24-h urine samples were collected once every 6 days.<bold>Results: </bold>368 spot urine and 230 24-h urine samples were analysed. The median urinary iodine concentration (UIC) was 140.5 (75.2, 246.9) μg/L. The estimated 24-h urinary iodine excretion (24-h UIE) values from spot urine samples and measured 24-h UIE values from 24-h urine samples were 348±240 μg/24h and 330±216 μg/24h (p=0.003), respectively. Irrespective of the urinary iodine method, the intra- individual coefficient of variation (CV%) was lower than the inter-individual CV%. Bland-Altman analysis revealed differences between spot urine and 24-h urine. When the precision ranges with 95% confidence were ±15%, ±20%, ±25% or 30%, the number of an individual's spot urine samples required were 30, 16, 11 or 8, respectively.<bold>Conclusions: </bold>Repeated spot urine is not a feasible way to assess recent individual iodine intake. The development of a multi-indicator system could provide an acceptable individual evaluation index of iodine status.
- Subjects
SHANXI Sheng (China); CHINA; IODINE; NUTRITIONAL assessment; CHINESE people; EXPERIMENTAL design; COMMUNITIES; URINE; URINE collection &; preservation; NUTRITIONAL status
- Publication
Asia Pacific Journal of Clinical Nutrition, 2020, Vol 29, Issue 4, p782
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.202012_29(4).0013