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- Title
A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.
- Authors
Pritchard, Lynn
- Abstract
Indicates that overexpression of human PKD1 transgene can elicit a cystic phenotype, suggesting that the level of polycystin-1 expression in mice may be relevant in human polycystic kidney disease. Generation of PKD1 transgenic mice; Comparison of transgene expression levels using the RNAse protection assay; Immunohistochemical analysis of polycystin-1 antibodies.
- Subjects
TRANSGENE expression; POLYCYSTIC kidney disease; PHENOTYPES; TRANSGENIC mice
- Publication
Human Molecular Genetics, 2000, Vol 9, Issue 18, p2617
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/9.18.2617