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- Title
The side and the location of the primary tumor does not affect the probability of lymph node invasion in patients with renal cell carcinoma.
- Authors
Nini, Alessandro; Larcher, Alessandro; Cazzaniga, Walter; Dell'Oglio, Paolo; Cianflone, Francesco; Muttin, Fabio; Ripa, Francesco; Salonia, Andrea; Briganti, Alberto; Montorsi, Francesco; Bertini, Roberto; Capitanio, Umberto
- Abstract
Purpose: To evaluate the role of side and location of the primary renal cell carcinoma (RCC) on the risk of lymph node invasion (LNI) and/or nodal progression (NP) during follow-up. Materials and methods: We evaluated 2485 patients with unilateral RCC, surgically treated in a single tertiary care referral center. Outcomes were LNI at surgery and/or NP during follow-up. We studied if RCC side (left vs. right) and location (upper vs. middle vs. hilar vs. lower area vs. more than one area) affected the probability of LNI and/or NP at follow-up. Results: Overall, 43 and 15% of patients underwent lymph node dissection and had LNI at surgery, respectively. During follow-up, 2.2% of patients had NP. Higher rates of LNI and NP were observed for patients with primary tumor located in more than one anatomical kidney area relative to patients with tumor in a single area (upper 11% vs. middle 10% vs. hilar 0%, vs. lower 12% vs. more than one area 26%, p < 0.01). cM1, cN1, pT2/pT3/pT4 disease and Fuhrman grade 3/4 were independent predictors of the study outcome (all p ≤ 0.01). Neither the RCC side nor the location reached the independent predictor status (all p > 0.1). Conclusions: Patients with single-side and more than one anatomical kidney area affected by RCC have higher rate of LNI at surgery and/or NP at follow-up. Neither side nor location of primary RCC tumor is related to the risk of harboring LNI at surgery and/or developing NP at follow-up.
- Subjects
RENAL cell carcinoma; LYMPHADENECTOMY; LYMPH nodes
- Publication
World Journal of Urology, 2019, Vol 37, Issue 8, p1623
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-018-2573-3