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- Title
Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges.
- Authors
Bron, Johannes Leendert; Helder, Marco N.; Meisel, Hans-Jorg; Van Royen, Barend J.; Smit, Theodoor H.
- Abstract
Lumbar discectomy is a very effective therapy for neurological decompression in patients suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineering strategies have been developed mainly targeted to the regeneration of the nucleus pulposus (NP) of the intervertebral disc. Accompanying techniques that deal with the damaged annulus fibrous are now increasingly recognised as mandatory in order to prevent re-herniation to increase the potential of NP repair and to confine NP replacement therapies. In the current review, the requirements, achievements and challenges in this quickly emerging field of research are discussed.
- Subjects
HERNIA; DISCECTOMY; NERVOUS system regeneration; ABDOMINAL diseases; NEUROLOGICAL nursing; THERAPEUTICS
- Publication
European Spine Journal, 2009, Vol 18, Issue 3, p301
- ISSN
0940-6719
- Publication type
Article
- DOI
10.1007/s00586-008-0856-x