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- Title
Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart.
- Authors
Brodde, Otto-Erich; Bruck, Heike; Leineweber, Kirsten; Seyfarth, Torsten
- Abstract
The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist α1-, β1- and β2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) α2-adrenoceptors. β1- and β2-adrenoceptors are quite evenly distributed in the human heart while M2-receptors are heterogeneously distributed (more receptors in atria than in ventricles). Stimulation of β1- and β2-adrenoceptors causes increases in heart rate and force of contraction while stimulation of M2-receptors decreases heart rate (directly in atria) and force of contraction (indirectly in ventricles). Pathological situations (such as heart failure) or pharmacological interventions (for example, β-blocker treatment) can alter the distribution of β1- and β2-adrenoceptors in the human heart, while M2-receptors are only marginally affected. On the other hand, relatively little is known on distribution and functional role of α1- and α2-adrenoceptor subtypes in the human heart.
- Subjects
HEART diseases; THERAPEUTICS; ADRENERGIC receptors; DISEASE complications; AUTONOMIC nervous system; HEART failure; CARDIAC arrest
- Publication
Basic Research in Cardiology, 2001, Vol 96, Issue 6, p528
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950170003