We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Translational biomarkers of acetaminophen-induced acute liver injury.
- Authors
Beger, Richard; Bhattacharyya, Sudeepa; Yang, Xi; Gill, Pritmohinder; Schnackenberg, Laura; Sun, Jinchun; James, Laura
- Abstract
Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.
- Subjects
ACETAMINOPHEN; BIOMARKERS; LIVER failure; NECROSIS; REACTIVE oxygen species; PROTEOMICS
- Publication
Archives of Toxicology, 2015, Vol 89, Issue 9, p1497
- ISSN
0340-5761
- Publication type
Article
- DOI
10.1007/s00204-015-1519-4