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- Title
Evaluation of Different Perfusion Durations in Direct Hemoperfusion with Polymyxin B-Immobilized Fiber Column Therapy for Acute Exacerbation of Interstitial Pneumonias.
- Authors
Kono, Masato; Suda, Takafumi; Enomoto, Noriyuki; Nakamura, Yutaro; Kaida, Yusuke; Hashimoto, Dai; Inui, Naoki; Mizuguchi, Tomoaki; Kato, Akihiko; Shirai, Toshihiro; Nakamura, Hirotoshi; Chida, Kingo
- Abstract
Background: Recently, the potential therapeutic effect of direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) has been reported for acute exacerbation of interstitial pneumonia (AE-IP), a highly morbid clinical event; however, there is no consensus on the appropriate procedure for PMX-DHP. We examined the appropriate perfusion duration of PMX-DHP for AE-IP. Methods: AE-IP patients receiving PMX-DHP were divided into two groups: short-duration group (≤6 h) (n = 5) and long-duration group (12 h) (n = 12). Results: ThePaO2/FiO2 (P/F) ratio increased immediately after PMX-DHP in the two groups. In the long-duration group, the P/F ratio continued to increase over the following 7 days, while, in the short-duration group, the P/F ratio declined again 3 days after therapy. The survival rate 30 days after PMX-DHP was significantly higher in the long-duration group than in the short-duration group. Conclusions: A long perfusion duration of PMX-DHP is more efficacious for AE-IP than a short perfusion duration. Copyright © 2011 S. Karger AG, Basel
- Subjects
PULMONARY fibrosis; PNEUMONIA; THERAPEUTICS; PERIPHERAL vascular diseases; IMMUNOSUPPRESSIVE agents
- Publication
Blood Purification, 2011, Vol 32, Issue 2, p75
- ISSN
0253-5068
- Publication type
Article
- DOI
10.1159/000320128