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- Title
Gamete intra-Fallopian transfer or in-vitro fertilization after failed ovarian stimulation and intrauterine insemination in unexplained infertility?
- Authors
Ranieri, M; Beckett, V A; Marchant, S; Kinis, A; Serhal, P
- Abstract
A prospective randomized study was designed to compare gamete intra-Fallopian transfer (GIFT) and in-vitro fertilization (IVF) and embryo transfer in the treatment of couples who have failed to conceive after at least three cycles of ovarian stimulation and intrauterine insemination (IUI). A total of 69 couples with primary unexplained infertility of at least 2 years' duration plus at least three failed cycles of ovarian stimulation and IUI were randomly allocated to either GIFT or IVF/embryo transfer. The clinical pregnancy rate was 34% after GIFT treatment and 50% after IVF/embryo transfer. This difference was not statistically significant. The twin rate in the IVF/embryo transfer group was higher than in the GIFT group (53 versus 17%, P = 0.005). We conclude that patients with unexplained infertility and failed ovarian stimulation and IUI can still achieve encouraging pregnancy rates with IVF/embryo transfer or GIFT. Since IVF/embryo transfer is the least invasive of the two procedures and may yield diagnostic information, we would favour this therapy; however, the number of embryos transferred should be reduced to two to reduce the risk of twin pregnancy.
- Subjects
CHORIONIC gonadotropins; LUTEINIZING hormone releasing hormone; HUMAN artificial insemination; BIRTH rate; COMPARATIVE studies; EMBRYO transfer; FERTILIZATION in vitro; HUMAN reproductive technology; LONGITUDINAL method; RESEARCH methodology; EVALUATION of medical care; MEDICAL cooperation; INDUCED ovulation; PREGNANCY; RESEARCH; TWINS; UTERUS; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; GAMETE intrafallopian transfer; THERAPEUTICS
- Publication
Human Reproduction, 1995, Vol 10, Issue 8, p2023
- ISSN
0268-1161
- Publication type
journal article