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- Title
Cancer to bone: a fatal attraction.
- Authors
Weilbaecher, Katherine N.; Guise, Theresa A.; McCauley, Laurie K.
- Abstract
When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumour-bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.
- Subjects
BONE metastasis; CANCER invasiveness; BONE fractures; OSTEOCLASTS; DIPHOSPHONATES; BONE remodeling; COLLAGENASES; OSTEOPONTIN; BONE resorption; BONES; BONE tumors; CELL physiology; CYTOKINES
- Publication
Nature Reviews Cancer, 2011, Vol 11, Issue 6, p411
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc3055