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- Title
Factors associated with discordant immuno-viral response in HIV-positive Peruvian adult people treated between 2005 and 2017.
- Authors
Carrasco Navarro, Roberto M.; Montalvo Otivo, Raúl Héctor; Clemente Lazo, Johana Ursula
- Abstract
Introduction: Discordant immuno-viral response, defined as a failure in increasing more than 100 CD4+ cells/µl T lymphocytes with an undetectable viral load at one year after initiation of a highly active antiretroviral therapy (HAART), is associated with an increase in mortality in people living with HIV (PLWH). This study explored a cohort of HIV-positive patients in a Peruvian hospital to determine factors associated with discordant immuno-viral response. Material and methods: A retrospective, analytical, cross-sectional single-site study was conducted, including PLWH receiving HAART with regular follow-up visits. In total, 310 PLWH, out of which 47 with a discordant response (DIR) and 263 with concordant immune response (CIR) fulfilled inclusion criteria for the study. Results: Main characteristics of our population were: age of onset of HAART around 35 years, male and heterosexual. Moreover, age over 65 years, from different hospital, co-infection, opportunistic infections, and baseline CD4+ > 250 cells/µl were significantly associated with DIR. Multivariate regression analysis showed basal CD4+ > 250 cells/µl and opportunistic infections associated with DIR. Conclusions: In our cohort, factors associated with the development of DIR are baseline CD4+ over 250 cells/µl and opportunistic infections.
- Subjects
PERU; HIV-positive persons; HOSPITALS; HIV infections; RESEARCH; PATIENT aftercare; OPPORTUNISTIC infections; VIRAL load; CROSS-sectional method; MULTIVARIATE analysis; RETROSPECTIVE studies; REGRESSION analysis; RISK assessment; HIGHLY active antiretroviral therapy; IMMUNITY; MIXED infections; T cells
- Publication
HIV & AIDS Review. International Journal of HIV-Related Problems, 2022, Vol 21, Issue 2, p164
- ISSN
1730-1270
- Publication type
Article
- DOI
10.5114/hivar.2022.115861