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- Title
MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1.
- Authors
Lin, Zhuo‐Yuan; Huang, Ya‐Qiang; Zhang, Yan‐Qiong; Han, Zhao‐Dong; He, Hui‐Chan; Ling, Xiao‐Hui; Fu, Xin; Dai, Qi‐Shan; Cai, Chao; Chen, Jia‐Hong; Liang, Yu‐Xiang; Jiang, Fu‐Neng; Zhong, Wei‐De; Wang, Fen; Wu, Chin‐Lee
- Abstract
Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR-224 is involved in PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR-224. Forced expression of miR-224 suppressed PCa cell proliferation, invasion and migration, and promoted cell apoptosis by downregulating TRIB1. Moreover, the expression level of miR-224 in PCa tissues was negatively correlated with that of TRIB1. miR-224 downregulation was frequently found in PCa tissues with metastasis, higher PSA level and clinical stage, whereas TRIB1 upregulation was significantly associated with metastasis. Both miR-224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence-free survival of patients with PCa. In conclusion, these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis.
- Publication
International Journal of Cancer, 2014, Vol 135, Issue 3, p541
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.28707