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- Title
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines.
- Authors
Tiecco, Giorgio; Degli Antoni, Melania; Storti, Samuele; Marchese, Valentina; Focà, Emanuele; Torti, Carlo; Castelli, Francesco; Quiros-Roldan, Eugenia
- Abstract
In 2021 the scientific community's efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease.
- Subjects
SEXUALLY transmitted diseases; SYPHILIS; PANDEMICS; PATHOGENESIS; SYMPTOMS; COVID-19 pandemic; DIAGNOSIS
- Publication
Pathogens, 2021, Vol 10, Issue 11, p1364
- ISSN
2076-0817
- Publication type
Article
- DOI
10.3390/pathogens10111364