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- Title
Safety and Efficacy of Different Concentrations of Atropine in Retarding the Myopia Progression.
- Authors
Khan, Hashim Ali; ur Rehman, Munib; Khanx, Qaim Ali; Shahzad, M. Aamir; Khan, Asad Ali; Mirza, Bilal Humayun
- Abstract
Purpose: To evaluate the safety and efficacy of different concentrations of topical atropine in retarding the progression of myopia. Method. A total of 90 individuals with bilateral myopia ranging between 2-6 diopters (spherical equivalent) with astigmatism of up to 1 diopter and ages ranging between 9-15 years of age were recruited. Patients were randomly assigned to one of three treatment arms i.e. 0.01%, 0.025%, and 0.05% atropine once daily in 1:1:1 ratio. All patients at baseline underwent cycloplegic refraction and axial length measurements. All patients were fully corrected for myopia and given +2.00 Diopters of near add in executive bifocals. Progression in Spherical equivalent and axial length were measured and compared across the three treatment arms was the main outcomes:. Results: After 1 year the mean [SD] progression of spherical equivalent was 0.48 [0.17] D, 0.38 [0.19] and 0.27[0.16] in 0.01%, 0.025% and 0.05% treatment groups respectively (p=0.00). The mean (SD] axial elongation was 0.16[0.06], 0.13[0.06] and 0.09 [0.05] mm in 0.01%, 0.025% and 0.05% treatment groups (p=0.00). None of the participants from 0.01% and 0.025% group reported any adverse events. However, 10% of patients from 0.05% group reported mild degree of transient photophobia. Conclusion: Low dose atropine can slow down myopia in a dose-dependent manner with relatively fewer side effects. Bifocals with near addition, when worn as standard spectacle during atropine therapy, may help further slowdown the progression.
- Subjects
PAKISTAN; ATROPINE; MYOPIA; LENGTH measurement; ASTIGMATISM; DRUG side effects
- Publication
Ophthalmology Update, 2020, Vol 18, Issue 4, p16
- ISSN
1993-2863
- Publication type
Article